Blar i ODA Open Digital Archive på forfatter "Størset, Elisabet"
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Evidence for solanidine as a dietary CYP2D6 biomarker: Significant correlation with risperidone metabolism
Wollmann, Birgit Malene Tovik; Smith, Robert Løvsletten; Kringen, Marianne K.; Ingelman-Sundberg, Magnus; Molden, Espen; Størset, Elisabet (Peer reviewed; Journal article, 2023)Aims: The extensive variability in cytochrome P450 2D6 (CYP2D6) metabolism is mainly caused by genetic polymorphisms. However, there is large, unexplained variability in CYP2D6 metabolism within CYP2D6 genotype subgroups. ... -
Prediction of CYP2D6 poor metabolizers by measurements of solanidine and metabolites—a study in 839 patients with known CYP2D6 genotype
Wollmann, Birgit Malene Tovik; Størset, Elisabet; Kringen, Marianne K.; Molden, Espen; Smith, Robert Løvsletten (Peer reviewed; Journal article, 2023)Purpose Poor metabolizers (PMs) of the highly polymorphic enzyme CYP2D6 are usually at high risk of adverse effects during standard recommended dosing of CYP2D6-metabolized drugs. We studied if the metabolism of solanidine, ... -
Pro-arrhythmic effect of escitalopram and citalopram at serum concentrations commonly observed in older patients – a study based on a cohort of 19,742 patients
Faraj, Pari; Størset, Elisabet; Hole, Kristine; Smith, Godfrey L; Molden, Espen; Dietrichs, Erik Sveberg (Peer reviewed; Journal article, 2023)Background For a decade, patients have been advised against using high citalopram- and escitalopram-doses due to risk for ventricular arrhythmia and cardiac arrest. Still, these drugs are widely used to treat depression ...